Ultimate Top 20 Phenibut FAQ

In this Ultimate Phenibut FAQ, we’ve tried to answer some of the top Phenibut questions that people ask! If you’ve ever wondered about how Phenibut works or how to take Phenibut, then this is the place to be!

This article will explain some of the top things about how Phenibut works and how to take it for stress reduction and calming purposes. This top supplement was developed in Russia as an anti-stress compound and was included in the Russian cosmonautics kit during their missions to space. Read up on the Ultimate Phenibut FAQ!

1.    What is Phenibut?

Phenibut is a psychoactive and calming substance that was developed in Russia in the early 1960s. Phenibut is said to have some calming, stress relieving effects, and to improve sociability. Phenibut works as a “GABA” agonist, in much the same way that alcohol and benzodiazepines work. Phenibut triggers ‘GABA-receptors’ in your brain, allowing you to feel more calm and relaxed when you take it.

2.    What is Phenibut’s chemical name?

The chemical name for Phenibut is: 4-amino-3-phenylbutyric acid. It’s SMILES structure is C1=CC=C(C=C1)C(CC(=O)O)CN. The molecular weight of Phenibut is 179.219 g/mol.

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3.    What kind of chemical is Phenibut?

The chemical structure of Phenibut. Source: PubChem open chemistry database

According to the PubChem open public chemistry database, Phenibut fits a number of characteristics. It is classified as an anticonvulsant, a GABA agonist (activates GABA receptors), a hypnotic or sedative, and a tranquilizing agent. Traditional tranquilizing agents tend to have relaxing effects on mood or thought, while hypnotics can be used to help with sleep.

4.    Why take Phenibut?

Phenibut was developed as a calming and stress-reducing substance. Most people who take Phenibut use it to help reduce feelings of stress. It can also be used to help maintain a calm mood and to help promote healthy sleep.

5.    What is Phenibut FAA?

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Phenibut FAA is the ‘free amino acid’ form of Phenibut. It is close to neutral pH and is moderately soluble in water. It is highly suitable for sublingual use (under the tongue) because of its neutral pH.  Phenibut FAA is the ‘pure’ form of Phenibut – around 99.5% purity. You’ll find that Phenibut FAA is a fine white powder and weighs less than Phenibut HCl due to a lower density.

6.    What is Phenibut HCl?

Phenibut HCl is the Hydrochloride form of Phenibut, made by reacting pure Phenibut FAA with hydrochloric acid. The HCl form of Phenibut is known as a zwitterion salt. It is dipolar, containing both a positive and negative charge. This means that Phenibut HCl is very easily dissolved in water, making it suitable for people who’d prefer to take Phenibut with juice or water. It is slightly acidic and has a sour taste. Most Phenibut available online is in the Phenibut HCl form.

7.    How to take Phenibut?

The way that you take your Phenibut depends on the type of Phenibut that you are using. Phenibut FAA is best taken sublingually, while Phenibut HCl is best taken in water. Using Phenibut regularly results in your body building up a tolerance. People also take Phenibut in capsules to avoid the sour taste.

8.    How long does Phenibut take to kick in?

You may have to wait a while before you feel Phenibut

Phenibut has a fairly long onset time of around 1.5 – 2 hours for most people. The time that it takes to kick in depends on the amount of food in your stomach, your metabolism, the dosage, and how you took it. Taking Phenibut sublingually results in a faster onset time that taking it with water or juice.

9.    How long does Phenibut last?

Phenibut’s long half-life is one of the things that people enjoy most about it. Most users report that the effects tend to last around 4 – 5 hours. A higher dosage normally lasts for longer. The length of time that you’ll feel the effects also depends on your metabolism and what’s in your stomach.

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10. Can you take Phenibut with alcohol?

Do not take Phenibut with alcohol! Phenibut and alcohol are both GABA agonists, triggering GABA-receptors in your brain. This is known as a ‘depressive’ effect because GABA is a ‘depressive’ neurotransmitter, slowing the signals from your central nervous system (CNS). Taking Phenibut with alcohol can cause dangerous negative effects like difficulty breathing, low blood pressure, and respiratory failure.

11. Is the Phenibut chemical dangerous?

The Phenibut chemical compound is classified under a few safety precautions. It causes skin irritation, serious eye irritation and may cause respiratory irritation if inhaled. Try to avoid prolonged skin contact and definitely avoid getting Phenibut in your eyes.

12. Can you take Phenibut with benzodiazepines?

No. Like alcohol, benzodiazepines also act as depressive substances, triggering your body’s GABA response and slowing CNS signals. Combining Phenibut and benzodiazepines can cause dangerous negative effects similar to the risk of combining Phenibut with alcohol.

13. Can you use Phenibut to replace alcohol?

Alcohol and Phenibut do not mix well together

Some people find that Phenibut’s effects in reducing stress and promoting calmness are very similar to those of alcohol. In this regard, some people choose to use Phenibut instead of alcohol. Some people claim that Phenibut makes them feel a lot more sociable.

14. What is Phenibut withdrawal?

Phenibut withdrawal happens after using Phenibut in high doses for a long time and stopping ‘cold turkey’. If you use Phenibut in high doses and without cycling, there is a risk that you will develop a Phenibut dependence. There is at least one case study of serious withdrawal effects after somebody developed Phenibut dependence and stopped taking it ‘cold turkey’.

15. Is Phenibut safe?

Phenibut is a skin and eye irritant. Taking Phenibut at the recommended dosage of under 1500mg per dose, and less than 2000mg per day does not usually result in adverse effects. Some users require higher doses while some are more sensitive to Phenibut. Overdosing on Phenibut is dangerous and can put your health at serious risk. Do not exceed the recommended dosage.

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16. What are the ‘neuroprotective effects’ of Phenibut?

Studies indicate that Phenibut may have neuroprotective effects

Lots of studies have pointed to what scientists call ‘neuroprotective effects’ of Phenibut. Most of these are animal studies but some human studies have shown the same effects. Neuroprotective effects mean that Phenibut may have the potential to protect your brain (neuro) from stress.

In one study, some unfortunate laboratory rats had a significant amount of their brain function destroyed when scientists blocked a cerebral artery (a technique known as transient middle cerebral artery occlusion (MCAO)). After seven days, the genes coding for brain cell growth were significantly higher in rats that had been given Phenibut. Other effects included a significant reduction in the volume of brain-damaged area, and a faster recovery. This model aimed to replicate the effects of a stroke.

17. What are the ‘cardioprotective effects’ of Phenibut?

Neuroprotective effects involve protecting your brain and cardio-protective effects involve protecting your heart. A few animal studies have indicated that Phenibut may also have some cardioprotective effects.

In one study, animals had a 32% alcohol solution injected into their stomachs until significant heart damage occurred. The Russian scientists found that a dose of around 50mg/kg significantly decreased the cardiotoxic effects of the alcohol solution.

Please note that the outcomes of animal studies and human studies often differ greatly. Phenibut is sold as a dietary supplement and is not intended to treat, diagnose, or cure any disease or ailment. Furthermore, mixing Phenibut with alcohol is dangerous to your health and can cause respiratory failure. Do not combine Phenibut with alcohol or any other GABA agonists.

18. Does Phenibut affect your immune system?

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At least one study has indicated that Phenibut may have effects on your immune system. Animal studies have pointed to the possibility of Phenibut being able to help maintain a healthy immune system, especially in response to immune stress.

Specifically, animals injected with lipopolysaccharide (LPS) responded with a hyperactive immune system. The scientists concluded that an injection of Phenibut seemed to remove the immune hyperactivity and restore phagocyte (type of immune-cell) activity. These results point to the possibility of Phenibut have positive effects on your immune system.

19. What is Phenibut cycling?

Phenibut cycling means using it on and off instead of every day. This helps to reduce the risk of developing a dependence. Phenibut can be addictive, especially when you use it every day and develop a tolerance.

A tolerance to Phenibut means that you require high doses to feel the same effects. Increasing your dose means more potential negative side effects and a higher risk of becoming dependent on it. We recommend cycling Phenibut by using it for no more than two days ‘on’ with a break of at least two days ‘off’.

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20. Can you get ‘high’ from Phenibut?

Phenibut isn’t used to get high. The effects are calming and stress-relieving. However, Phenibut’s effects also vary from person to person. Some people feel the effects very strongly while others don’t feel them at all. Unfortunately, this is just the way that Phenibut seems to work. We highly advise against using Phenibut to try get to ‘high’.

Conclusion

Phenibut has calming and relaxing effects which may help alleviate stress

In conclusion, Phenibut is a powerful calming and stress-relieving compound. It’s one of the most used calming supplements available today. It does not create a feeling of being high but it helps to reduce stress and to promote a calm mood and healthy sleep. However, it’s important to know about the risks of Phenibut before using it.

While it is a great supplement, there is a risk of developing a dependence and experiencing negative side effects, especially if you use it in high doses for a long period of time without cycling. Phenibut may have negative interactions with a number of medications and is definitely not to be used with alcohol or benzodiazepines.

References:

I Lapin, “Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug”, CNS Drug Rev. 2001 Winter;7(4):471-81.

4-Amino-3-Phenylbutanoic Acid, Pubchem, Open Chemistry Database, CID 14114, retrieved on December 15, 2016

AV Samokhvalov et al., “Phenibut dependence”, BMJ Case Rep. 2013; 2013, PMC3604470

Tiurenkov IN, “[Psychotropic effect of phenibut salts and their compositions with organic acids]”, Eksp Klin Farmakol. 2011;74(2):3-7.

MA Samotrueva et al., “[Immune-regulating effect of phenibut under lipopolysaccharide-induced immune stress conditions].”, Eksp Klin Farmakol. 2010 May;73(5):30-2.

VV Bagmetova, “Effects of Phenibut and Citrocard on Non-Competitive and Competitive Behavior during Provoked Aggression in Animals”, Bull Exp Biol Med. 2015 May;159(1):48-52

E Vavers et al., “The neuroprotective effects of R-phenibut after focal cerebral ischemia”, Pharmacol Res. 2016 Nov;113(Pt B):796-801

VN Perfilova et al., “[Cardioprotective effect of GABA derivatives in acute alcohol intoxication],” Eksp Klin Farmakol. 2006 Jul-Aug;69(4):23-7.

DR Owen et al., “Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity”, Drug Alcohol Rev. 2016 Sep;35(5):591-6, Epub 2015 Dec 23.

Dambrova M et al., “Comparative pharmacological activity of optical isomers of phenibut”, Eur J Pharmacol. 2008 Mar 31;583(1):128-34, Epub 2008 Jan 26.

“Phenibut”, PubChem, open Chemistry database, retrieved on January 4, 2017

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